Nurse cell Biology of Trichinella spiralis
نویسندگان
چکیده
Trichinella spiralis is unique among all known nematodes in being the only species to occupy an intra-multicellular niche in the body of its host. Like developing tumours they also need to recruit new blood vessels towards the developing nurse cells to meet the ever-growing demand of nutrients. Like viruses they highjack the cell machinery and physiology so as to ensure their growth. Thus, interfering with the key steps in their development of nurse cells like angiogenesis and collagen synthesis can effectively control Trichinellosis.
منابع مشابه
Verifiable Hypotheses for Thymosin β4-Dependent and -Independent Angiogenic Induction of Trichinella spiralis-Triggered Nurse Cell Formation
Trichinella spiralis has been reported to induce angiogenesis for nutrient supply and waste disposal by the induction of the angiogenic molecule vascular endothelial cell growth factor (VEGF) during nurse cell formation. However, the action mechanism to induce VEGF in nurse cells by T. spiralis is not known. Hypoxia in nurse cells was suggested as a possible mechanism; however, the presence of ...
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